CELECOXIB BLOCKS VASCULOGENIC MIMICRY VIA AN OFF-TARGET EFFECT TO RADIOSENSITIZE LUNG CANCER CELLS: AN EXPERIMENTAL STUDY

Celecoxib Blocks Vasculogenic Mimicry via an Off-Target Effect to Radiosensitize Lung Cancer Cells: An Experimental Study

The resistance to radiotherapy in lung cancer can be attributed to vasculogenic mimicry (VM) to some extent.Celecoxib (CXB), a selective inhibitor of cyclooxygenase-2 (COX-2), is reported as a radiosensitizer in non-small cell lung cancer (NSCLC).However, whether CXB can regulate VM formation via an off-target effect to radiosensitize NSCLC remains

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Spinal Anesthesia Using Chloroprocaine is Safe, Effective, and Facilitates Earlier Discharge in Selected Fast-track Total Hip Arthroplasty

Background: Spinal anesthetic choice plays an underappreciated role in total hip arthroplasty (THA).Chloroprocaine, a short-acting local anesthetic, has been limited to short-duration ambulatory procedures and has not been studied in THA.We compare perioperative outcomes of patients undergoing fast-track THA using chloroprocaine spinal anesthesia w

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Clinical Utility of Anorectal Manometry in Children with Functional Constipation: Can Anorectal Manometry Help Predict the Therapeutic Response?

Background: Anorectal Manometry (ARM) plays a crucial role in diagnosing potential motility disorders of anorectum in pediatric gastroenterology.Despite its prevalence, the predictive utility of ARM in guiding therapeutic response remains poorly characterized.Objectives: This study aims to evaluate the effectiveness of ARM in predicting therapeutic

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Smoking-related interstitial fibrosis combined with pulmonary emphysema: computed tomography-pathologic correlative study using lobectomy specimens

Hideji Otani,1 Tomonori Tanaka,2 Kiyoshi Murata,1 Junya Fukuoka,2 Norihisa Nitta,1 Yukihiro Nagatani,1 Akinaga Sonoda,1 Masashi Takahashi3 1Department of Radiology, Shiga University of Medical Science, Setatsukinowa-cho, Otsu, Shiga, 2Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, 3Departmen

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